In 2004, co-founders Chris Lester and Kayne Fisher opened Natty Greene's Brewing Co. in downtown Greensboro with the idea to push the limits with ales and sours. Natty Greene's, named after Greensboro's namesake Nathanael Greene, quickly become
In 2007, Natty Greene's expanded into a production brewery to begin distribution throughout North Carolina. By 2014, Natty Greene's brews could be found from Virginia to South Carolina. In 2016, Natty Greene's expanded once again through a multi phase project that brings Natty Greene's Kitchen + Market and new Brewery to Revolution Mill in Greensboro, NC.