Louise C. Smith was born on August 7, 1904 in Wadesboro, North Carolina. Upon the death of her father, a minister, the family of seven moved to Greensboro. Smith attended Woman's College of the University of North Carolina (now The University of North Carolina at Greensboro) and graduated in 1927. She also attended classes in Columbia University and the University of North Carolina.
From 1928 to 1931 Smith served as a teacher in the Danville, Virginia, school system and then left for another teaching job in a one-room, twelve grade school in West Virginia. After a year, she left West Virginia for a teaching job in Durham, N.C. where she boarded with a wealthy family and roomed with a classmate from Woman’s College. Smith eventually relocated to Greensboro where she taught high school in the public school system. When the Brown v. Board of Education decision was announced in 1954, she was the first instructor to volunteer to have an African-American in her class. Smith died on October 22, 1992 at the age of 88.